Clotrimazole Cream 1 Cost
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Bactrim - a combined drug, containing two active ingredients: sulfanamide drug sulfamethoxazole and derivative of diaminopyrimidine - trimethoprimum. Colibacillus life activity oppresses that leads to reduction of synthesis of thymine, riboflavinum, niacin, etc. group B vitamins in intestines. Duration of therapeutic effect makes 7 years.
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An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria.
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Clotrimazole-betamethasone cost ratio is more than twice the cost of niflumide-etoposide.
The authors of this study note that, because of the lower cost and shorter duration of action clotrimazole, "clotrimazole may have greater clinical benefits than niflumide-etoposide in patients with moderate renal failure."
Clotrimazole is indicated in patients with moderate to severe active inflammatory urticaria and in patients with severe, persistent urticaria due to steroid therapy.
Clotrimazole should be used as an adjunctive therapy in patients with end-stage renal disease (ESRD), including patients with advanced end-stage renal disease who are receiving diuretics or diuretic-sparing therapy, if tolerated.
Clotrimazole is indicated when used for a period of 30 days or more to treat persistent urticaria caused by steroid therapy.
Clotrimazole-etoposide should be used in patients with stable renal disease (ESRD or mild insufficiency), with without co-morbidities.
Clotrimazole-etoposide is not recommended for patients with acute renal failure (ARF) or non-ASCII disease, such as the cystic fibrosis syndrome, because of the increased risk serious adverse events.
Clotrimazole is not recommended for use in patients with advanced renal failure when used on its own.
Clotrimazole-etoposide should be given at the lowest effective dose.
Adverse Reactions
Clotrimazole-etoposide may be associated with a lower incidence of adverse effects than clotrimazole.
Adverse reactions are primarily reported in patients with active inflammatory urticaria, which are often associated with anaphylaxis (anaphylactic contact dermatitis) or anaphylactoid reactions (anaphylactoid requiring emergency treatment by a healthcare provider).
Clotrimazole-etoposide is associated with a reduced rate of anaphylaxis (a hypersensitivity reaction) compared to clotrimazole.
Clotrimazole-etoposide may cause adverse reactions in patients with asthma or an acute exacerbation of asthma (e.g., when used for prolonged periods of time or in association with other drugs that aggravate asthma), including anaphylaxis, angioedema, and/or angioedema-type reactions.
Clotrimazole-etoposide is associated with a higher than expected incidence of drug-related adverse reactions. Patients taking clotrimazole with inhaled corticosteroids or steroids, as well patients who previously had an anaphylactic reaction to oral clotrimazole, are at a higher risk for developing adverse reactions to the combination of clotrimazole-etoposide and other drugs.
Clotrimazole-etoposide may cause anaphylaxis when Enalapril similar drugs given to patients who have previously experienced an anaphylactic reaction to clotrimazole.
Clotrimazole-etoposide is associated with a higher incidence of other adverse reactions than clotrimazole, including:
Anaphylaxis: anaphylaxis is an allergic reaction that occurs when someone's immune system mistakenly attacks a specific area of the body. It occurs when a person's immune system accidentally attacks the area of body to which it is allergic (skin, eyes, throat, or lungs) the area that it mistakenly attacks (intestines). The body's reaction to an antigen (a substance the body does not recognize as harmful) is also known an antibody reaction. Anaphylaxis can occur at any time without prior exposure to an antigen; however, it typically occurs during the first hour or so of exposure to an antigen.
angioedema: angioedema is a swelling (swelling or discomfort in parts of the body) caused by an increase in the production (or release) of chemicals (hormones) in the body. It may be accompanied by other symptoms, such as an upset stomach or diarrhea, tenderness, redness.
anaphylaxis: anaphylaxis is an allergic reaction that occurs when someone's immune system mistakenly attacks a specific area of the body. It occurs when a person's immune system mistakenly attacks the area of body to which it is allergic (skin, eyes, throat, or lungs) the area that it mistakenly attacks (intestines). The body's reaction to an antigen (a substance the body does not recognize as harmful) is also known an antibody reaction. Anaphylaxis can occur at any time without prior exposure to an antigen;
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